When you say "locked down by a luthier" you mean decking or blocking it so that it doesn't float? If so, then no, that is not an issue.
If, on the other hand, you mean replacing the existing trem with something like a Floyd Rose locking trem, then I could see that possibly becoming an issue depending on who does the install. I would send it to the PTC or someone like Joe Knaggs* for that kind of work to ensure it looks like it was built that from the factory.
* I'm not sure if Joe will work on the occasional PRS guitar or if he only builds his own these days, but he worked at PRS for 25 years and has a lot of experience with them.