I have personally only ever owned PRS guitars with a wide fat or a wide thin neck profile. Never had anything new enough to have switched over to the "pattern" stuff. Nor have I owned any SE's or S2's. But for me, wide fat is the most comfortable. Now, intuitively, you'd think, with my little hands, that the smaller the neck, the better. But, for some reason, that wide fat just seems "solid" in a way that I didn't get from the wide thin. Maybe it was because my main guitar when I was young was a full hollow, 335 type of guitar with a thicker neck. And maybe I just "got used" to that kind of a feel. But it is almost like the support of having a little bit of something resting in my palm is a little easier to work with than if my palm pulls up off of the back of the neck (can you tell I am no classically trained guitarist??) Anyway, This was my old Sukova archtop that I spent a lot of time with in my late teens/early 20's....and a pic of how small my hand is. Interested you you all's input on neck size and feel.