You will want to have your string slots on the nut widened, so the strings don't bind when you do bends or use the trem.
If you're a big trem user, I would highly recommend locking tuners and a Tusq XL nut. The slots on the TUSQ nut are more of a bowl shape (vs the deep slots on PRS nuts), and it's a lot more forgiving to trem use and string gauge changes. I put one on my SE CU24 and it's the most stable of all my trem equipped guitars, including my S2's with USA PRS nuts.