I haven't tried the larger Headrush Pedalboard yet but since I have tried the smaller Gigboard, I feel like it's all I need. The Gigboard and the Pedalboard sounds exactly the same tone-wise, except that the Gigboard is smaller with fewer footswtiches. You can assign patches to each switch anyway and in my experience, I never needed more than 4 patches in one song. User-wise, the generous 7" screen is excellent! It's just you are using a traditional physical pedal. You can drag a pedal and switch it's order. Double-click on a pedal and then change the parameters to adjust your tone. On stage (I rarely do) I use it with the Headrush FRFR cab. It has am xlr line output that you can feed to your venue's main board and use your FRFR cab as your monitor. So, all you need to bring to a gig is your guitar/s, Gigboard (or Pedalboard), the FRFR cab, and the necessary cables. It's really convenient.
It also has a very cool 20-minute looper, so you can record yourself play, then play it, go to the back of your venue place to listen to how your set up sounds.
You may absolutely plug it into your combo. You can do the 4-cable on it, or plug into its return in its loop or power amp in. I used to plug my ex-mfx into the power amp in of my combo. However, eversince I tried the Headrush FRFR cab, I was sold to it and disposed all my amps giving me more room in my home studio. The FRFR is full range-flat response and it is like painting on a blank canvas. Everything is crystal clear and exactly how I want it to sound.
You may want to look at the Boss GT-1000 too. You can adjust your tone via bluetooth. Record your guitar on the built-in looper, go to the back of the room and adjust your tone on your phone or tablet via bluetooth. It's tuner is also polyphonic cutting tuning time. I loved the tuner on my ex GT-100.