Not usually. S2 SC's are pretty much on spec from the factory...plekking the guitar would be gilding the lily, so to speak, and unnecessary.
Only thing you might need, if the guitar is being purchased used, is to perform a string change, intonation and set-up...the PRS website support page can show you how...and will save you about $80 in the process if perhaps you own the correct tools to do the job...
What helped me was adjusting the neck truss rod, the intonation, and pickup height. All part of the process you can do yourself with a machinist's rule, a wide flat head screwdriver, a precision small flat head screwdriver, and a precision Phillip's head screwdriver.
If necessary here are some YT videos of John Ingraham's PRS videos...which explains a good portion of how to do the DIY intonation and set-up.