PRS CE 22 - can it handle 12 guage strings tuned 1/2 step down?

Mine came with 11s which were binding in the nut - 10s now on it which are fine. The guitar should handle 12s ok but you may well need to get the nut slots widened.
 
The guy I bought mine from had it setup for C# with some big strings, handled it with no problems. He didn't file the nut and just didn't use the trem.
 
I think you should be fine, maybe if you add an extra spring on the tremolo to be safe
 
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