Wow, some great posts here! It's fun to hear what everyone instantly bonds with, don't ask me why, it just fascinates me. And, it's not a bad way to learn about some sweet gear to keep an eye out for! There are also some mentions here that don't surprise me a bit, but are fun to hear nonetheless - HXDA, Soldano, Boogie, and all those PRS guitars!
I'll take my turn now.
Guitars - I've had 3 that hit the spot right away, in chronological order: SE Akesson, S2 Studio, and WL594. They just sounded and felt "right" immediately.
Although, I should mention, I'm giving a small exception to my 594 here, I had one of the ones with a bent bridge plate, and it wasn't up to its full sonic potential until I discovered that. It always sounded good, but it didn't have the note attack and string-to-string definition that I expected out of the 594. Until I swapped the (identical) bridge off my S2 594 when I saw the bend in the core model's bridge, and it just opened the guitar right up, immediately. It's been perfect ever since (I did order a new bridge for it and return the S2 bridge to its home). So, in the form it was meant to be, my 594 is perfect.
Amps - I love PRS amps, but I will say, they're not always easy for me to just turn on and get the sound I want immediately - they pay off with more organic tones than many "instant gratification" amps, once you get to know them. The HDRX 20, however, was instant magic. Others have been the '66 Super and Friedman Smallbox. Hmm... all those were basically in the last year... it's been a great year for amps!
Keep 'em comin, fellas!