Big +1 to Mozzi on this one... his descriptions of the attributes of each guitar are spot on. It really depends on what you want to do. The CE is more of, dare I say, the "Classic Electric" in terms of its utility, it's a rock guitar that can foray into jazzy stuff a little more than a full solid body. The SE is the opposite, more of a jazz box that can go into rock on occasion. So I would recommend considering what your purpose for the guitar will be.
Regarding neck profiles, if you're a Strat player, the CE may have the most familiar profile for you. At the nut, perhaps a touch wider than some vintage spec Strat necks, the more modern high-end Strats are about the same width. As far as the shape, I find the Pattern Thin on the CE is ever so slightly flatter on the back than most Strats I try, although we're talking minutiae here, it's by no means a flat back profile, just leans very slightly that way. The SE W/F is fatter compared to Pattern Thin (or W/T) in a similar way that some Tele necks are fatter than Strat necks - it's that kind of size difference, but worth noting the W/F still doesn't have as much meat on the edges the way a baseball bat of a Tele neck does. The thickness may be similar, but the W/F is more petite coming around the edges so that it still doesn't feel like an unmanageable handful. I have fairly small hands too, and have never had a problem with either profile, both are very comfortable, and really not vastly different from each other. Like siblings that you see a strong family resemblence in.
You may also like the Pattern Regular carve of the S2's if you have small hands. Best way I can describe it is as a petite version of W/F. It's thinner at the nut and front to back, but still has a rounder profile than Pattern Thin (or W/F). Very comfortable for me. The S2 semi hollow 22 is a unique instrument - it's subdued at the top end and thick sounding. If you wanted the most straight-forward, punchiest rock oriented instrument, it would be the CE, if you want to be closer to a big body jazz box, the SE, and the S2 fits somewhere in between. Hope that helps!