If using some different tunings and string gauges, the adjustable stoptail on PRS gives you the most adjustment. Not only do you have the individual saddles to adjust like on a tune o matic style, you have the 2 set screws on the studs if you need to bring the whole bridge or 1/2 of it to compensate. I go as heavy as a .60 for a low C or B.
I have a guitar in B F# B G B E with 60, 52, 36, 17, 13, 10 with the PRS adjustable stoptail. Also my normal drop C with 60 52 36 18 14 11 gauge. Both intonate properly.