Beyond leaving a fairly large hole in the top of a PRS if you remove the trem bridge and install a stop tail, you can cause another problem.
If memory serves, the neck angle on a stop tail PRS is different from the neck angle on a trem model, because the trem bridge is lower to the body of the guitar.
Any bridge you install would need to sit no higher than the current bridge you own, since otherwise you'd be changing the break angle of the strings. The neck angle and break angle matter both to tone and playability.
Before installing a stop tail, you might want to get more info. A lot more info. You could be opening a larger can of worms than you might think. On the other hand, you could simply have a Floyd Rose installed, and block the trem. That would solve your problem, and the modification would simply be routing the top to accommodate the Floyd.