I’m a high gain player. I thought the same for a long time. I switched from EMG and Super Distortion to PAF style pickups around 2006 thinking I was onto something. Improved articulation from the pickups, let the amp do the heavy lifting. My idea was reinforced when I found out the Lamb of God guys were doing something similar.
I initially liked it, but for a long time I was unhappy with my sound. I blamed a lot of things, thought my tastes were changing, it took me a long time to realize it was the pickups. A couple years ago I started to clue in, made some changes and now half my guitars are high output (JB) while the other are low (58/15 and 85/15).
The pickups are the source and PAFs have weak midrange. Overwinding increases midrange and reduces top end. Feed that into a clean amp and it sounds dull and sterile, but feed it into a high gain amp and you start getting harmonics that you never realize existed if all you’ve ever used is vintage output. Stack on the output and compression and you start needing less gain on the amp. Hotter signal, fatter tone, screaming leads.
I won’t get the same result by boosting the mids on a PAF... I tried. I can’t boost what was never there in the first place, and I can’t shift the harmonics on a PAF using a tubescreamer.
All the harmonics on a PAF are higher up... sounds great clean and good overdriven, but keep rolling on the distortion it comes across as increased fizz... the stuff everyone is trying to EQ out. The end result is flat, boring, and lacks the cut in the mix. Add in the mush from an Alnico 2 magnet to the much from dirt and it’s not a recipe for success.
PAF style pickups are great sounding pickups for some things and they’re terrible for others. IMO, they’re just one option out of many and shouldn’t be put on the pedestal some like to put them on.
IMO and YMMV.