D2's are my go to. I have only played 85/15's a couple of times, and it wasn't in MY guitars. So I really didn't have time to dial anything in. I am pretty sure, with some tweaking of settings there is overlap there where they can sound similar.
The neck D2 is my favorite neck pup. It is warm AND bright at the same time (if that makes any since) but it is more warm than bright. I believe it is around 8k so it "can" push an amp.
The bridge is closer to 12k, so you can drive the crap out of the amp if you desire. The catch is that if I use it alone, I roll off the tone a bit so it isn't as heavy on the highs.
My sweet spot (And bear in mind, I play rhythm in my band, and the music isn't excessively distorted. More, clean or "overdriven" as far as what roll I play) is to play BOTH neck and bridge at the same time. What this seems to do is gives me huge sound, and the best of both of the pickups while mitigating anything annoying that I might find in either of them.
It is VERY subjective. And with the D2's, what I find is that people either really like them....OR they really DON'T. If you can find an old CE or Cu22 from the early 2000s that you can play, try it out. That should give you a feel for what they might be able to do for you.
(Pic, just because it's fun
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