That's definitely a challenge for sure. The key for me is having my guitar set-up properly, using efficient left hand technique (not mashing the f6ck out of each note), using alternate picking the whole way through, and not overthinking the pattern. Moving it down to the F# is even harder. Leave it to Lifeson.
Out of the songs our band played (we didn't play Jacob's Ladder or La Villa, the other guys didn't feel like they could do them justice, although our set list was still stacked <
( ), the hardest for me was Freewill on account of that blistering solo. I would sh!t a brick until we stepped up to that song and once it was done, the rest of the show was easier.
I think the tallest challenge with Lifeson's playing is to interpret his parts correctly. It's often you'll see bu77shit interpretations of his parts online for most of his songs. Many of his parts are much different than you might think. And once I learn what the correct part actually is, it's not uncommon I have to choose a compromise that gets the point across. Like the C major chord at the end of the verse on Tom Sawyer. It's not a C major barre chord. That works in a pinch, but it's THIS:
e|---------0-----------0-------------3--------------0-----
B|---------9-----------5-------------3--------------3-----
G|---------9-----------7-------------2--------------5-----
D|---------9-----------7-------------2--------------5-----
A|---------7-----------7-------------0--------------5-----
E|--0-0-0-0---0-0-0-0------0-0-0----------0-0-0-------
I understand this is a pot that wants to be stirred, so have fun with that.