So this is going to sound dumb... but...
I've only ever played my Studio through my Mesa Mark V. All of my other amps are Fenders with 10" speakers (Princeton Reverb, Vibrolux Reverb, BassmanRI). These amps HATE humbucker guitars, particularly neck humbuckers. So I tried my Studio through my PR. This guitar really gives up the goods. Particularly the neck pickup. I'm serious, this may be the guitar I've waited for for a very long time. I spoke to my local dealer today, and asked him if there might be any more floating around... we'll see.