PRS by a mile, and I'm not saying that just because I'm on a PRS forum. I've owned and worked on many Epi LP's. Epi LP's (and some of this I direct at the LP design in general) are bloody heavy, clunky, factory soldering can be a turd festival, though on a positive note they do play well enough and neck stability is passable. That said, I sold or donated the ones I owned and will never buy one again.
By comparison any SE is superior. The 245, Tremonti, or Zach are perfect alternatives if you want a singlecut axe: Much lighter, good fretwork, an LP shape but far more comfortable to play, but most important the truss rods are just gold. They are very responsive and contribute to a very stable instrument, meaning less trips to the repair shop. It will be worth the extra dough to go for the PRS. You will not regret it. I sure as hell dont.