Everyone's got their thing, and whatever works for the player, works.
Years ago, I produced and played keys and bass (and believe it or not accordion on one Americana track!) on a project in Europe with Laurie Wisefield (Wishbone Ash, Eric Clapton, Joe Cocker, Ringo Starr's All Stars, etc). He's certainly one of the most incredible players I've ever been lucky enough to work with, and he sounded fantastic. And when I say fantastic, feel free to read that as 'best ever'. Ever. Really. Soaring, brilliant solos. Genius stuff.
'65 Strat >> Script Dyna Comp >> Marshall JTM45 reissue >> 4x12 Marshall cab. He had a couple of other things on his board, but didn't use them.
Laurie played with the JTM 45 cranked in the recording room, and he was in the control room so he wouldn't go deaf. I simply can't put into words how fantastic he sounded, but so much of it was his gorgeous, lyrical playing, and his mastery of the art of guitar.
Also one of the nicest people to work with ever. A great experience. But yeah, he used that frickin' Dyna Comp, an old one.
For me, the Dyna Comp never worked, but I think with a Strat a little extra schmaltz is needed to thicken things up, and of course, the cranked JTM45 didn't hurt. He had that amp going.
I worked with him the following year as well. What a great experience!