I'm going to take a rather unpopular position in the whole tone wood debate here... the one in between.
I believe wood does matter. I have a Swamp Ash Special and a 25th McCarty that need tons of gain before they start sounding interchangeable. Clean, they're worlds apart and the pickups and the build are as close as they'll ever be. So I'm sold on that point.
But: I believe there's a saturation point. If, for argument's sake, we assume a simple direct correlation between price and quality of wood and put that on the X axis and we put quality of tone on the Y axis, the difference between a $100 and a $500 guitar is going to be much greater than between a $1.000 and a $5.000 guitar. The $500 guitar is still not going to sound 5x as good as the $100 guitar but very noticeably better. The $1.000 guitar and the $5.000 guitar you'd probably have to hold in your own hands to tell the difference. Not saying there is none but it's not going to be the determining factor on any given record or stage.
In my mind, PRS guitars generally are far beyond that saturation point where they'd easily be "good enough". They're uncompromising products of a search for perfection beyond rationale. Now, the S2 line seems like a much "saner" purchase, still approaching that technically ideal point between price and quality from the top end but much closer to it.
I'll still happily spend way too much on a guitar I love. Sanity isn't always the most determining factor behind decisions that lead to happiness.