Disagree. Sometimes multiple buffers can be the issue, but not always. It’s unpredictable. and in his most recent post the OP said he turned off the Boss Waza tuner buffer and his issue went away - so it seems like this exactly what was causing the problem, two buffers in a row. i have several boss pedals on my board, and they are fine. Most aren’t in a row though. But newer Boss buffers got significantly better, not sure when exactly but older boss pedals sometimes had a bad reputation and newer Boss pedals seldom have this complaint.
The other thing to try is the Mesa buffer last in the chain. What I find surprising, unless maybe you’re running several really long cables is that you need a buffer with not A lot of pedals To restore your high end. That seems unusual to me.
A buffer doesn't affect the level. The OP stated that it seems the input level going into the Boss is too hot. Buffers don't do that. I've yet to see a Boss pedal affected by a buffer that precedes the pedal.
Maybe if something's not working on the Boss pedal...possible.
I had a BD-2 on a pedalboard following a high quality buffer many years ago, and it did fine (in fact, that buffer was built by the very person Mesa hired to design their buffers).
It's true that certain vintage style pedals don't work well after a buffer. The Boss pedal isn't one of them.
Some pedalboards don't need a buffer, some do. It's going to depend on a lot of factors. But in my 32 years of studio work, and setting up recording gear in a variety of settings, I've yet to see two buffers in a row cause a problem (vintage style pedals like some fuzzes and wahs excepted).
In my studio, I run a 15 foot, very low capacitance cable (16pF/foot) to my pedalboard. But I have ten pedals on the board, each with its own cabling (and let's not forget that plugs also add capacitance). After going through all the pedals, I run a 20 foot cable to a KHE amp and cabinet switcher, and from there, 10-20 foot cables go from the switcher to each amp's input.
So I run a buffer at the beginning of my pedalboard chain, and another at the end of my pedalboard chain. The sound quality is stellar.
I've never, ever had a buffer cause a problem, except with vintage fuzzes or wahs. I'd need to see that demonstrated. Not that I feel I shouldn't believe you - I simply haven't observed it.