There is nothing wrong with the S2 but the 57/08s 59/09s 53/10s (now out of production) and the DGTs are as good as any humbuckers I've ever heard. The core models sound much better as a result. Couple this with the core model playability and you've got a winner.
I love my Les Paul for it's tone. I love my PRS because it sounds great, feels great and plays better than pretty much any other manufacturers guitar I've ever played.
Take your time with this purchase, it's worth it. I think the first thing you need to decide is what you want. Body shape, tone, scale length, it all makes a difference and PRS has something for everyone, you just need to find the one for you.