I find myself asking if you ask this question because you genuinely don't know, or if you know and want to sit back and munch popcorn!
Assuming the former: guitar amplification is about so much more than making a small signal large and putting it through speakers. Every guitar amp ever has introduced some amount of distortion of the original signal. Originally that was due to technological limitations of 1930's electronic technology. Then certain kinds of distortion got to be considered desirable, and guitar amps were refined more and more to enhance the distortion and gain available. Of course, some players wanted more, some players wanted less. In about the 1960s, builders started trying to replace vacuum tubes in the guitar amps with transistors, which were the new miracle electronics technology. The results were... bad and players started caring about tube vs. solid state amps. Tubes won out in the market of public opinion. But guitar amp technology kept getting refined on both sides of that split. Today the choice isn't as simple as "tube vs. solid state" because there are 1.) amps with elements of both, 2.) digitally-controlled amps with analog signal paths, 3.) digital modeling of vacuum tube amps, and 4.) digital power amps. Plus I'm sure there are variations I haven't thought to mention here. One of my favorite guitar-noise things is the Fractal series of digital modelers, and if I remember correctly, that was created by a guy who came from a sonar data processing background.
Small moons worth of electrons, barrels of ink, and probably no small amount of blood have been spilled on the topic of which of these things are "best," but I won't go there. My take: we've kind of got all of the above these days. Except maybe the electric car parts.