I recently purchased a PRS SE Custom 24 25th Anniversary Edition guitar, and I'm loving it so far! While researching my purchase, I found that the biggest complaint about SE Custom 24's were the pickups (yes, I realize this is subjective.) There were conflicting opinions of them, too. Either "lifeless" or "too muddy" or "too brittle/bright." When I got it, I plugged it into my Peavey Bandit 112. Overall, I was very pleased with the sound. I found the pickups to be quite clear and articulate. The bridge pickup was on the bright side, but rolling back the treble on my amp a bit took care of that pretty quickly. The following video helped me out quite a bit, as I've had the same Duncan pickups in an Epiphone G-400: Is there a difference? Sure! Is it a $150-$200 difference? Not to my ears. At this point, it seems like we're in some cork-sniffing territory to me. But that's just me!