Great post! This is something I think about often. It's as relevant to creating a good recording as it is playing live. You want the instrument to be able to handle the parts and still add to the overall sound, yet have some "cut" and identity. In a recording context, of course, you can carve out some room for an instrument with EQ, but that's tougher to do in a reverberant live setting unless you have a major touring mixing rig.
Anyway, for me it comes down to whether there are other guitarists on the stage, what parts I'm playing, whether there are keys, and the style of music. My CU22s have always been my first choice as a general purpose guitar in most ensembles. But if I was the only guitar player, I'd probably pick an SC with 57/08s to cover a lot of ground. I find I can get a ton of chime with a few tricks I have up my sleeve in any case.
Honestly, when I am mostly playing parts with chime, I like a 12 string.