The 2 extra frets pushe the neck pickup closer to the bridge. The effect is some loss of fullness or roundness for the neck pickup - the neck pup on a 24 fretter will sound a bit thinner than it would if it were farther from the bridge. So you start with a slightly brighter tone on a 24 and a slightly darker tone on a 22.
On a 24, there will be a greatly diminished 9th fret pinch harmonic since one of the nodes (where the string is not vibration and thus not moving to produce a signal within a magnetic field) is sitting right over the neck pup. on a 22 fretter, that node is off of the neck pup by as much as an inch. The result is the 9th fret harmonic is noticeably louder on a 22 fretter than a 24 fretter.
Since most luthiers (including PRS) overlay about 2 frets on the body at the neck joint for electric guitars, your finger access to frets 21 and 22 will be easier on a 24 fretter because they are not overlaying the body.
The bridge on a 24 fretter will be farther from the heel of the guitar and closer to the neck because the entire bridge-fretboard-nut scale is laid to only have 2 frets overlaying the body. This leaves more room between the bridge and tail of the guitar. That can be good or bad depending on your personal build and playing style and/or where you prefer your controls.
All of these things are rather subjective for the feel and playability of the guitar and amount largely to personal perferences for the position of things and your desired tone.
The only thing that cannot be easily compensated for is the relative weakness of the 9th fret harmonic on a 24 fretter. Physics is a cold taskmaster.