Even though I have problems with my hands on occasion I have no real issues playing my Vela. I use the 10 - 46 gage on mine.
The only thing I've noticed is; because the neck shape is not as wide and not as deep as my other guitars, it's almost like I have to "think ahead" with what I'm doing. I really have to concentrate on the positioning of my fretting hand more so with the Vela than with my other guitars. If I don't do that then certain things feel stiff. But as they say, your mileage may vary.
All in all I'm better of with a neck that's a bit wider and deeper and the Vela's a different little beast for sure. But oh, those tones!!