It's too bad you missed that Sweetwater deal on the SE 245, Smokey.
I think the SE Custom 24 and Santana are two very classic SE models that I own. But I have two singlecuts, which are also awesome guitars - an SE Singlecut Tremolo tobacco sunburst, and the new SE Tremonti Custom black/grey flame. These two singlecuts sound great, feel great, and play really well.
All of my SE's sound different, aside from the fact that they apparently have the same pickups for the most part. The Custom 24 has the bass HFS and SE treble pickups. I think my older Singlecut Tremolo might have different pickups too, but they all sound great stock. These are equal to the best stock guitars that I have owned when it comes to pickups, and the build quality is unequalled.
If you want a tremolo the SE Santana is the way to go and you get a classy guitar, double cuts are very nice looking, etc. All the elements are there. If you want more of a LP type vibe, go with the 245 - it won't be an LP but it will be a great guitar. I don't think you can go wrong either way, but that Tremonti Custom black/grey is awesome, as well as the Custom 24.
It's a good choice to have to make. More than a few dudes would be more than happy to own any one of these guitars.