I have an S2 Standard 22 that I'm really enjoying. Right now I have no plans on changing the pickups but you never know. What size humbucker fits? 50mm or 53mm?
Any humbucker should fit. I have not measured the pole spacing (which is what you're referring to) on a S2 but the G&Bs on the SEs are 52mm bridge and 50mm neck. The US and S2 bridges are swappable so I would assume the string spacing is the same. PRS USA pickups are 49.2mm. In other words, whatever you want to put in there will be fine.
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