I don't doubt that some people have trouble keeping their trem equipped PRS in tune, but I occasionally wonder if it's user error and ignorance (I don't mean that in a jerky way) instead of the guitar or its craftsmanship that are to blame, or if people have unreasonable expectations of a single-locking tremolo.
If your nut is cut for a smaller gauge of strings it will bind and you will have issues. If you have wraps of string around your locking tuner posts it's not the guitars fault, you're simply doing it wrong. There should never be any wraps of excess string around your post, doing so will negate the purpose of locking tuners in the first place. If you don't stretch your strings the guitar will of course go out of tune, and the same will happen if you don't tune "up" to pitch rather than "down" because of the slack created in the gear of the tuner. If you're concerned that your guitar is out of tune after sitting in its case or on a stand in a non-humidified environment for a few days... IDK, tune it.
This isn't directed at anybody in this thread, or the twenty other threads that pop up about this same topic every month, I just don't have any problems keeping my PRS in tune after I check for all of the above. The SE trem block can add another wrinkle if the holes are not smooth enough for the string-ball to enter freely and I have come across that, but never on a core model PRS.