I did this to both pick ups as shown in the picture and they really do make a difference in tone. The bridge is thicker and the neck cuts through a little more. Also the middle position split Sounds a little more 2 or 4 in between positions Strat like. I don’t think there’s any change in humbucker tone at all.I notice the core versions of the 35th Anniversary Custom 24 and Paul’s guitar have the neck pickup reversed, while the S2 and SE versions do not.
I am tempted to flip the neck pickup in my SE 35th CU24 ... it should sound slightly different when split.