Hi Daniel! I have an S2 with the #7's, I would say they are a low output, vintage inspired pickup. Lots of mids, subdued highs. The USA #7's are supposedly moderate output with a modern twist, but that's not what I hear in the S2 7's... just my opinion though. But I do love the tone, if you want a classic rock or blues vibe and don't need a lot of push, you'll love them. The HFS/VB set is more modern and the bridge pickup packs a lot of heat. If you're into metal or harder rock, they're a good pick, although I don't prefer the tone as much. But that's just me.
All that being said, I wouldn't pick your new S2 on pickups alone. The 22 will have a little more warmth in the neck pickup, because its further from the bridge than in the 24 (the extra 2 frets pushes the neck pickup back). The 24 will be a little tighter and more articulate in the neck pickup. You can always swap pickups, I would imagine you could get a different set of S2 pickups on the bay easily.