I just got my first PRS. I have long been a loyal fan of Gibson and James Tyler but this ME5 really blew my mind. I just fell in love with the new pickups and Northern Lights finish. The curly maple top sure is flamy. The TCI-tuned pickups are great and the coil splits on both PU's are fantastic. I am afraid I have never used any 408's, Cu's or any other PRS before so I can't really make any comparison to those but I think this one is truly versatile for sure. It has a warm and sparkly clean tone, both with the middle pickup and coil splits. Also, I can still hear the harmonics even at a high gain setting when using the humbuckers. I have had Madagascar rosewood fretboard on James Tyler, Ebony on my R57. Though I can't really tell if the Brazilian rosewood fretboard makes much difference but I am impressed with the build quality and sound of this new guitar. Well done, Paul.