Here are some initial thoughts.
As expected, the P22 feels really good and is very easy to play. This particular example is also pretty light, not that I care about the weight a whole lot. Fingerboard is nice and, like other PRS models with this same cut, it's easy to hold.
I guess I'm a little surprised at how aggressive the tone from this guitar is on my home amps. The amp I tested it on at the store was a Marshall JCM900, and it sounded wonderful through that at all volumes. But it doesn't seem to like a Fargen Retro Classic, which is a surprise as I would have thought that would be a perfect fit for this guitar. Don't get me wrong, it sounds good through the Retro, just not great. Compared to my Les Paul, which simply refused to produce a bad tone on the Retro, I have to dial things back quite a bit with the P22, otherwise it just seems to produce a woody, bassy, and slightly messy kind of sound with the channel volume around noon. That same setting churned out an outstanding classic rock crunch on the Les Paul (Wildwood underwound pickups), but I suppose every guitar is different and takes some time to dial in with a particular amp. Nevertheless, so far I don't really dig it paired with the Retro.
Surprisingly enough, the P22 loves my Mesa Mark V. That's kind of a shock to me as I would have thought it would be a much better match with the Retro, but it just seems to feed off the Mark V and spit out some really in-your-face-type modern rock sounds. That really wasn't what I originally had in mind when I bought this guitar but... I'm kind of pleased with the way it turned out to be honest. It doesn't quite sound like anything else I can think of.
Moving on to channel 3, which is the really heavy gain channel on the Mark V, the P22 loves it. Imagine that! This thing throws down a John Petrucci modern metal sound with ease, and surprisingly enough, the neck works pretty well for this kind of heavy music. A little effort with the settings even produced a tone which sort of reminded me of Evanescence. What the hell is going on here? I don't know, but I like it.
The cool thing about this guitar is that it's able to spit out modern grind, but with a flick of a switch you can go into acoustic land and just chill with some mellow tunes. Having all that come from one guitar is pretty damn cool if you ask me.