If you’re running drives or compressors in the loop, that’s probably your issue. The signal running through your effects loop is much hotter than coming from your guitar and will instantly overload any gain stage pedal like that, really you should put those in front of the amp, and save the loop for time based effects and perhaps modulation. Or, if you want to run a preamp drive pedal into the MT15 power amp, you would want to run your guitar into the pedal and then the pedal into the effects return only.
Have you tried simply plugging a single cable directly into the send and return? If the amp works properly doing so, it’s a pedal issue.
Apologies if I’m misunderstanding your issue.