Well, I just got my ME V yesterday so take this with that in mind. It is probably the most versatile guitar I've ever owned in terms of a standard electric guitar (piezo and/or Roland pickup equipped guitars obviously offer significantly more potential options). The humbuckers sound great and the single coil tones are the best tapped humbuckers I've heard. Prior to this, I would have said my 594 had the best tapped humbuckers.
The ME V has a big bottom end. The Strat 2 & 4 positions with the pickups tapped sound great. Also, the ME-V has a switch to use 250/500k pots. When you're playing single coils, switching to the 250k takes a bit of the edge off.
The Custom 24 is really a quite different guitar - you've got standard humbuckers, a neck pickup placed closer to the bridge, and no middle pickup.