Guitars built with different woods will sound different, period. Your post seems a bit (needlessly) antagonistic, and I highly doubt you speak for the "majority of people out there." Certainly you are entitled to your own opinion, but stating people who are anal about the type of woods that are going into a guitar they like/dislike are a joke is just silly.
A PRS with a mahogany neck compared to one with identical specs with the exception of adding a maple neck instead absolutely won't sound the same, even with the same player/same amp/etc. regardless of the natural "personal" tone their fingers provide. Your ears alone should be able to tell you that...