I have played for years with a clean amp and a full assortment of pedals going into the preamp. Just recently I decided that I would take my reverb pedal and put it into the effects loop of my amp. A big improvement especially if I have engaged an OD pedal. Next up, I plan to do the same thing with my delay pedal. The journey continues....& I admit, I embrace new ideas and technologies (example - amp profilers) very cautiously. Prefer to focus on the music and not so much on the gear.