The guitar tuning is way off and there is a delay when you play.
I'm not really experienced with, or particularly in love with, Rocksmith 2014, but I like the idea of using a real guitar lot more than playing with the plastic controllers of guitar hero. I like the direction this technology is going in, and am a fan of Rocksmith the same way I'm a fan of bicycles-for-rent on every street corner even though I never ride a bike.
That said, I think the tuning is fine. It forces you to tune your guitar every time you play a song, I think, and it tunes you to whatever that song is tuned to. A LOT of songs are not using instruments tuned to A440. Maybe that's what you're noticing?
I also had delay or latency problems on my PS3 using the HDMI-TV cable, and the delay problems were drastically improved when I used the component cables for audio from PS3-to-mixer instead of the TV. I'm using the P22's dual outputs to send the Mags to Rocksmith and the Piezo to my Kemper. The latency makes it sound like a very short slapback delay. If I'm just hearing Rocksmith, I can tell there is some latency, but it's tolerable to me. Not ideal, but tolerable.
A way bigger problem for me, I find the way the notes come at you on the screen really confusing still. I haven't been able to get used to it. I get so lost I'm just staring at the colored blips coming at me like a deer in headlights. My brain does not want to compute that.