Mozzi,
Could you compare the neck profiles of these guitars? Some of us have hands that the necks just feel better with (no joke).
I find this quite difficult because they are not too extremely different to me and going between my most extreme neck shape differences doesn't really feel that extreme to me. Its not like going from an ultra thin 'Wizard' neck to a chunky wide and thick baseball bat of a neck and I don't really feel like I notice much difference that takes more than a second of thought. I find going from my Custom 24 (Pattern Thin) to my 594 (Pattern Vintage) - the two biggest extremes of PRS necks (at least in mine as I don't own older PRS that are not 'pattern'), takes any thought or time to adjust - the biggest adjustment for me is more the switching and pot layout. Wanting to go from Bridge to Neck (or vice versa) takes much more 'thought' and I find myself going to switch PU's and searching for the switch position. Some of that is inherent from always playing LP type guitars so its 'easier' to go from Custom 24 to 594.
I know the neck is extremely important but for me, these differences are not so extreme that it really matters to me. All mine are regular PRS gloss necks, no satin or natural wood so feel the same in that sense. The Pattern Vintage with the asymmetric carve to me is more like 'home' and a lot of that maybe because the overall design and layout is much more familiar to me as a LP player before I was able to get my first PRS. As an LP player, it made sense for me to get the 594 first so again that maybe why it feels most at 'home' for me.
I can't comment on the McCarty or the Custom 22 as I think that may be a different neck to my PRS Special 22 (Pattern Regular vs Pattern) but switching between my Pattern and Pattern regular guitars feel remarkably similar in my hands. They may have some differences but I really don't give it any thought. Going between them, its more the 'big' differences in layout, weight and functionality that register. Going between the 509 (solid with a 25.25" scale, 5 SC PU's, trem bridge etc), to my HBii (Hollow with Piezo static bridge and double HB's) to my PRS Special 22 (semi Hollow, added NF in the middle), the neck differences don't really register, doesn't affect the way I play and, any difference is immediately and automatically adjusted for as the all the other differences require a bit more thought and adjustment to. That's also the case when I go from Cu24 to these its a very similar shape if just a bit thinner.
Maybe a lot of it is psychological too as they all look similar from the top, all have the same headstock. The one that stands out most to me is the Pattern Vintage and some of that is also the way the strings feel with the shorter scale length. I admit the guitar I play the least is my 509 which has the longest scale length and I see it more as my guitar for Tele/strat options - probably under estimating its HB functionality but having a 594 (classic LP Humbucking tones), my Cu24 (more modern PRS HB tones), My HBii (Hollowbody and Piezo with great HB's too) and most recently, my PRS Special 22 (a Custom 22 with the NF adding extra functionality - the 58/15s are great HB's and great tapped too), its pushed my 509 down and why it rarely gets used for its HB qualities.
I am sure there are people here who can be a lot more helpful in describing the different neck profiles and there are threads dedicated to this very thing. From my perspective, I would notice something if it didn't feel right, made me have to adjust my playing, caused me to think and/or be aware of the neck shape over any other differences and even if it only affected me after 'hours' of playing. The fact that none really require much thought although as I said, the Pattern Vintage does feel 'different', more 'broken in' than the others but that's a momentary thought, is a good thing. I don't want to pick up a guitar and find myself having to get used to the neck carve as well as the different positions of switches, knobs etc.
Sorry I can't be more helpful than that and, if you do want more info, I would suggest you check the forums for Neck Carve differences.