The thing with guitar amps is that, in my experience, no matter how good your amp tone is, or the model you use in your Kemper, etc, low volume never sounds as good as high volume. There's something in the way the air compresses in front of the speaker (or inside the cab), or the room responds to the sonic waves, or "something" that just doesn't happen at "bedroom" volumes. So when I play at bedroom volumes, I don't try to chase that "oomph".
Here is something that every guitar player should try at least once. Take Julie Bowen and Sofia Vergara to a deserted island. Then... wait, that's not the topic I was asked to speak on today.
Not that everyone shouldn't try that.
Ok, take a flat power amp (SS PA amp, Power Station, etc) and run first a white noise signal for test one and a full range music track for test 2. Start with very low volume. Then "bedroom volume." Then turn it up a bit. Then more and more until it's loud.
This test allows you to clearly here a number of things. First, how the frequency response changes with increase volume (F-M Curve). This one is our ears/brain changing, not the gear. Second, how that with some volume, your speaker cone starts to contribute it's own breakup and, how it's tonal balance seems to change with volume. Most guitar speakers breakup and how they do really affects the sound and the louder it is, the more it affects it. We all know this, right? But have you ever determined exactly where it starts to break up (what volume level) exactly what it does to the tone, and how/if you re-dial the amp when it does? And while we're at it, same for the FM curve... you need to adjust bass and treble as volume goes up even if the speaker didn't change. Third, we hear how your cab starts to contribute (assuming closed back cab). The damping provided by a closed back cab will at some level be heard as part of the "thump" we associate with guitar cabs. Do this with white noise then a full range music track. You'll discover the details of what all happens when we turn up a speaker/cab
So when we say "crank the amp to it's sweet spot" we can never discount the contribution of the speaker(s) and cab as they too have a sweet spot. If you're lucky, they are in the same dB range, but many times they are not. Obviously, this relationship can be manipulated. Don't want cone breakup to "muddy up" your magic tone? Use a higher powered speaker known for no cone breakup. Want it at a lower volume? Use lower wattage speakers with smaller magnets (usually), less cone edge damping, less stiff cone, etc.
After this test, run a second one where you run those same to test signals through your guitar amp and into that cab. Now you can see where the amp starts to contribute it's thing to the final tone. And, if there is not a synergistic match, you can see how to address that. As Paul always says, everything affects everything. Even my favorite speaker so far, is not my favorite with every amp or cab. I have been openly not a big V30 fan because the spike is ice picky with MOST amps. But in a big room, up loud, the spike is "cut" not ice pick, so I often mix one other speaker in a 2x12 with a V30 so I get a bit of that but much better sound in a smaller room.
All this said to make one point. "Crank the amp to it's sweet spot" is very often someone hitting the volume level at which their cab sounds best. While the response of many amps changes with volume (especially if it has less pre-amp gain and you're pushing the PI stage into OD, like a JCM800 for example) I think we're many times hitting the volume the cab sounds great, as much as hitting the amps sweet spot. Yes, this varies with literally every amp-speaker/cab combination, but seemingly EVERYONE says "the amps sweet spot" when it's often the speaker/cab's sweet spot, or could be the amps sweet spot, or if your really lucky, both.
IMO, YMMV, consult your physician for erections lasting over 4 hours.