From my experience in playing Custom Shop Jackson guitars, and the difficulty in selling them, I can offer this:
Not every one-off guitar speaks to a lot of buyers. If one that is spec'd in a way that appeals to you, as a buyer, then that's great. But, a lot of times, a one-off is just enough outside of the box that most players aren't willing to shell out the cash.
Most of my CS Jackson's were based on the PC1, which is a mahogany body, quilted top, bolt-on with a quilted fretboard. It made for a nice, classy base. Surprisingly they were hard to sell because my one-off specs weren't globally appealing to Jackson players. Dyo, I'd sell at a significant loss to move an instrument.
When I'd spec Custom Soloists, I'd still lose money, but not as much because some of the Jackson hallmarks were there: NTB, and a pointy head stock.
I know when I'm dropping big dollars on gear it needs to fit exactly what I want. I see some good deal PS guitars, but they are still priced high enough that I get picky enough to pass.