I'm straight in. Sometimes I think I need a delay because some songs call for it, but I like making as much of that sound as I can with reverb and my fingers. I have a few pedals but almost never break them out.
I mean...that's straight in all right...straight into a pair of A/D converters, then to to a model incorporating an IR of a different amp (in other words a recording of that amp), which is then digitally processed, and then out to a D/A converter, and through more analog circuitry.
Kind of a stretch to say it isn't a more processed sound than using pedals in front of an analog amp.
On the other hand, if it works for you, then my goodness, it works and more power to ya!