22 fret owners, any issues playing a 24 fret guitar?

Ive always played 22 fret guitars, my 4 PRSi are all 22 fret, I kinda look at the fretboard as a grid but I have a line on a CE that is 24 frets, anyone have any trouble playing on both?

It's only in your head...
 
I have just the opposite issue, not terribly but a 22 felt strange now I have and play 24 fret PRS electric guitars. Personal preference
 
I find scale length to be en equal factor, sometimes even body shape. My comfort zone is 22 frets @ 24.75" or 25" scale. So my SE Custom 24 Floyd feel odd because it's both 24 frets and a 25.5" scale neck. And then my SE Santana feels a bit cramped w/ 22 frets but on a 24.5" scale and a body shape that pushes the guitar backward when sitting down.

So the DGT is just about perfect for me. Which is why I picked up a used CE-22 instead of a CE-24. Maybe it wouldn't have been a big deal, but I went with my gut.
 
Heart-shaped and purple?;)

No silly! Like this.....

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