The 52 and whatever the larger size on the A string may cause some binding at the nut. I put a thicker set of strings on my SE 7 with no need to tweak, and I put a thicker "top string" on my SE Holcomb (so it is a C string) without any issue. But maybe I am less finicky to minor binding in the nut.
I don't know if you will need much of a tweak in your setup, it isn't like you are going to 11s from 9s, you are doing the equivalent of a half-step up in string gauge. Also, if your set up was done for the 10s tuned to E, and you downtune to E flat, the extra tension from the slightly thicker set will be like going back to normal E (roughly).
I dunno, maybe, as mentioned I am just not good enough of a player to notice, but I don't tweak stuff when I change string gauges - I just slap them on and keep playing.